
**Natera Unveils Updated ALTAIR Clinical Trial Analyses at ASCOâGI 2026**
âĒBy ADMIN
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Natera, Inc. (NASDAQ: NTRA), a global leader in cellâfree DNA and precision medicine, announced updated findings from the PhaseâŊIII ALTAIR clinical trial that will be presented at the 2026 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCOâGI) from JanuaryâŊ8â10, 2026. The ALTAIR trial (NCT04457297) is a randomized, doubleâblind study evaluating the impact of Trifluridine/Tipiracil (FTD/TPI) on molecular recurrence in patients with stageâŊIâIV colorectal cancer who tested positive with Nateraâs SignateraâĒ circulating tumor DNA (ctDNA) assay.
A postâhoc blinded central radiographic review revealed that FTD/TPI significantly improved diseaseâfree survival (DFS) versus placebo, with median DFS of 9.23âŊmonths compared to 5.55âŊmonths and a hazard ratio (HR) of 0.75 (95âŊ%âŊCI:âŊ0.55â0.98; PâŊ=âŊ0.0406), marking a meaningful update from earlier analyses that showed only numerical benefit.
In addition to the ALTAIR results, Natera will highlight a largeâscale study showing that rapid increases in Signatera ctDNA levels (doubling time in one month or less) are linked to shorter recurrenceâfree survival, underscoring the value of ctDNA dynamics in relapse risk assessment and personalized management strategies for colorectal cancer patients.
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